{"id":12247,"date":"2026-07-02T14:36:57","date_gmt":"2026-07-02T14:36:57","guid":{"rendered":"https:\/\/www.bedfont.com\/?p=12247"},"modified":"2026-07-02T14:37:00","modified_gmt":"2026-07-02T14:37:00","slug":"the-evolution-of-feno-testing-from-laboratory-systems-to-point-of-care-diagnostics","status":"publish","type":"post","link":"https:\/\/www.bedfont.com\/pt-pt\/the-evolution-of-feno-testing-from-laboratory-systems-to-point-of-care-diagnostics\/","title":{"rendered":"The evolution of FeNO testing: from laboratory systems to point-of-care diagnostics"},"content":{"rendered":"\n
\n
\n

Asthma is a chronic disease that affects millions worldwide, with many dying from the condition every year1<\/sup>. Asthma care has evolved over the years, but despite the advances, objectively assessing airway inflammation, the key driver of asthma, remains challenging in routine clinical practice.<\/p>\n\n\n\n

Historically, asthma management has relied heavily on symptom reporting, but symptoms alone are unreliable indicators of airway inflammation. Inflammation in the airways cannot be seen, and whilst patients may appear clinically stable, airway inflammation may be present, necessitating the use of objective, measurable biomarkers.<\/p>\n\n\n\n

FeNO \u2013 A non-invasive biomarker technology<\/strong><\/h2>\n\n\n\n

Airway inflammation is associated with elevated levels of nitric oxide (NO) in exhaled breath, providing a measurable biomarker of eosinophilic inflammation known as Fractional exhaled Nitric Oxide (FeNO). Using a FeNO device, clinicians can rapidly assess airway inflammation through a non-invasive test that delivers real-time results to support asthma diagnosis, monitoring, and treatment optimisation.<\/p>\n<\/div>\n\n\n\n

\n
\"Evolution<\/figure>\n<\/div>\n<\/div>\n\n\n\n

The evolution of FeNO technology<\/strong><\/h2>\n\n\n\n

In the 1990s, researchers found that FeNO served as a non-invasive biomarker of airway inflammation and used chemiluminescence technology to measure it, detecting NO through light emitted during a chemical reaction. This method provided high sensitivity and accuracy but proved very costly due to the need for regular maintenance and calibration, limited accessibility, and the specialist training required to operate it. It was clear that early FeNO technology demonstrated clinical value but lacked scalability.<\/p>\n\n\n\n

In recent years, this has advanced to electrochemical sensor technology, enabling a new generation of portable FeNO devices, including the NObreath\u00ae, whilst still matching the gold-standard chemiluminescence technology.<\/p>\n\n\n\n

Modern FeNO devices using electrochemical sensors have decentralised diagnostics, providing a portable respiratory diagnostic option which is easy to integrate into point-of-care workflows. The devices are easy to use and no longer require specialist training, making them a more cost-effective option in respiratory diagnostics.<\/p>\n\n\n\n

\n
\n
\"Evolution<\/figure>\n<\/div>\n\n\n\n
\n

How point-of-care FeNO testing changes clinical practice<\/strong><\/h2>\n\n\n\n

Thanks to continuous innovation, FeNO devices are now accessible at the point of care, enabling faster clinical decision-making, improved monitoring capabilities, and more personalised asthma management. This evolution reflects a broader shift toward decentralised, non-invasive diagnostic technologies designed to support earlier detection and more proactive respiratory care.<\/p>\n<\/div>\n<\/div>\n\n\n\n

FeNO testing \u2013 Ease of use<\/strong><\/h2>\n\n\n\n

Recent developments in FeNO devices have focused on usability, workflow efficiency, and accessibility. For example, the NObreath\u00ae, now in its 2nd<\/sup> generation, is a portable FeNO device which pioneered the exhalation-only manoeuvre. Helping to improve asthma care for over 15 years, the device is suitable for both adults and children, the test is easy to complete and provides a flow incentive to ensure a flow rate of 50 ml\/s, yielding an accurate result. Providing instant results, FeNO testing supports efficient point-of-care workflows and faster clinical decision-making.<\/p>\n\n\n\n

The future of respiratory diagnostics<\/strong><\/h2>\n\n\n\n

The inclusion of FeNO testing in clinical guidelines has increased throughout the years, with the 2024 UK guidance from the National Institute for Health and Care Excellence (NICE), the British Thoracic Society (BTS), and the Scottish Intercollegiate Guidelines Network (SIGN) recommending FeNO as a first-line test to aid asthma diagnosis and management2<\/sup>.<\/p>\n\n\n\n

\n
\n

This marks a major shift in asthma care, with a growing emphasis on biomarker-led approaches and more personalised treatment strategies to improve patient outcomes. As respiratory diagnostics become increasingly accessible beyond hospitals and specialist centres, more patients can benefit from advanced technologies through primary care, community clinics, and outpatient respiratory services. Reflecting this trend, Intermedical UK, the exclusive UK distributor of the NObreath\u00ae<\/a> FeNO device, has now installed more than 3,000 devices across the UK, including over 1,200 since the 2024 guideline update, highlighting the rapid adoption of FeNO testing in routine clinical practice.<\/p>\n\n\n\n

FeNO testing offers a non-invasive option to aid diagnosis and monitoring of asthma, making biomarker testing more accessible and decentralising respiratory monitoring. Continued innovation in this technology may even expand to home monitoring in the future.<\/p>\n<\/div>\n\n\n\n

\n
\"NObreath\u00ae<\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n

References<\/strong><\/h3>\n\n\n\n
    \n
  1. World Health Organization. Asthma [Internet]. World Health Organization. 2024. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/asthma<\/a><\/li>\n\n\n\n
  2. National Institute for Health and Care Excellence. Overview | Asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN) | Guidance | NICE [Internet]. Nice.org.uk. NICE; 2024. Available from: https:\/\/www.nice.org.uk\/guidance\/NG245<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Asthma is a chronic disease that affects millions worldwide, with many dying from the condition every year1. Asthma care has evolved over the years, but despite the advances, objectively assessing airway inflammation, the key driver of asthma, remains challenging in routine clinical practice. Historically, asthma management has relied heavily on symptom reporting, but symptoms alone […]<\/p>\n","protected":false},"author":11,"featured_media":12292,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[149,55],"tags":[234,174,8,9,157,168,154,155,11,156],"class_list":["post-12247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","category-nobreath","tag-advancing-feno-technology","tag-asthma-care","tag-bedfont","tag-bedfont-scientific","tag-breath-analysis","tag-feno","tag-feno-testing","tag-improving-asthma-care","tag-innovating-health","tag-nobreath"],"acf":[],"yoast_head":"\nThe Evolution of FeNO Testing<\/title>\n<meta name=\"description\" content=\"This article looks at the evolution of FeNO testing, from early technology such as chemiluminescence to modern electrochemical sensors.\" \/>\n<meta name=\"robots\" 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